Russell Brand's reign as host of the MTV Video Music Awards is over.
Chelsea Handler will host the 2010 VMAs. Handler broke the news Wednesday on her late-night talk show, "Chelsea Lately," MTV reports.
Brand hosted the show in 2008 and 2009.
The show airs live from Nokia Theatre in Los Angeles on Sunday, Sept. 12, at 9 p.m.
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Scheduled performers include Kanye West, Justin Bieber, B.o.B and Florence and the Machine.
Lady Gaga leads the nominees for the MTV Video Music Awards 2010, scoring 13 nominations. It's the most nominations for one artist ever in a single VMA year.
Lady Gaga has two videos nominated in the Video of the Year category: "Bad Romance" and "Telephone," her collaboration with Beyonce.