Joanne Blankenship of Preston, Ga. won a $365,000 house in the St. Jude Dream Home Giveaway on Sunday.
Blankenship and her husband Aaron are retired shop owners.
"I was shocked," she said of winning.
The contest raised $571,300 for St. Jude Children's Research Hospital.
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Among other winners was Nancy Peters of Warner Robins, Ga. who won a 2011 Toyota Camry.