Agents with the Metro Narcotics Task Force on Thursday raided the T&T Food Mart on Warm Springs Road at the bridge over I-185, confiscating four gambling machines and what agents suspect is the synthetic drug spice.
Arrested were employees Krunal V. Jani, 29, and Harshad L. Patel, 61.
Lt. Charlie Kennedy said both were charged with commercial gambling which is a felony and keeping a place of gambling which is a misdemeanor.
They will appear in Columbus Recorder's Court Friday at 2 p.m.
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Kennedy said they will likely also face drug charges if the suspected spice sent to the crime lab proves to be a controlled substance.
Kennedy said task force officers had also expected to find bath salts but did not.
Kennedy said the task force operation has been under way for about six months, with T&T Food Mart just one of several businesses agents have been monitoring.
"It is one of the places we have been getting complaints about," Kennedy said.
The gambling machines were paying off in cash, which is illegal in Georgia, he said. The machines were out in the open.
Similar raids may follow at other businesses, he said.