Fourth-ranked Columbus State will be going for its third NCAA Southeast Regional championship when it plays Lenoir-Rhyne at 5 p.m. Friday.
The match will be played at Rollins College in Winter Park, Fla.
Columbus State, which is undefeated at 20-0-1 and the top seed in the region, advanced with a 1-0 double-overtime victory over Wingate on Nov. 16 at the Walden Soccer Complex.
The Lady Cougars advanced when Kelcey Pelletier scored in the 104th minute.
Lenoir-Rhyne, which is 16-3-3 and the second seed, also won Sunday at home. It needed penalty kicks to beat North Georgia.
This will be CSU's fifth trip to the region championship match. It is 2-2, winning in 2007 and 2008, losing in 2009 and 2012.
The two teams have met six times with the series even at 2-2-2. Both of Lenoir-Rhyne's wins have come in the NCAA tournament. The Bears won 1-0 in 2010 and on penalty kicks in 2011.
The last time they met came during the regular season in 2012. Stephanie Lowery and Blakely Heideman scored in a 2-1 CSU win.
The CSU-Lenoir-Rhyne winner will face the Rollins-Saint Leo winner on Sunday in the national quarterfinals. Rollins and Saint Leo play at 7:30 p.m. Friday.
A trip to the final four in Louisville will be at stake.