Auburn coach Gus Malzahn issued a short statement Sunday afternoon wishing defensive coordinator Will Muschamp well.
Malzahn's statement came on the heels of South Carolina football's official Twitter account announcing the hire.
Muschamp is expected to be introduced in Columbia on Monday.
"I really appreciate Coach Muschamp’s hard work and dedication for our program at Auburn this past year and wish him nothing but the best with his new job. I will begin a search immediately for our next defensive coordinator."
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The Tigers former defensive coordinator's second stint with the program lasted less than a full year.
Malzahn hired Muschamp to replace Ellis Johnson, who he fired at the end of the 2014 season.